ALFRED BENNUN, PH.D.

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IV. PROFESSIONAL ACTIVITIES

A. INVITED   LECTURES

1959 - Institute of Cellular Biology, School of Medicine, Univ. of Cordoba, Argentina

1961 - Seminar Program, Laboratory for Ceil Metabolism, National Atomic Energy Commission and Institute of Biochemistry, School of Medicine, University of Buenos Aires.

1961 - Department of Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires.

1962 - Institute of Biochemistry, School of Medicine, University of Buenos Aires.

1964 - Seminar Program, Section of Biochemistry, Weizmam Institute of Sciences and Dept. of Molecular Biology, Neizmann Ist. of Sciences.

1965 - Dept. of Physiology and Pharmacology, Duke university, Durham, North Carolina

1965 - Biochemistry Section, Public Health Research Institute of the City of New York, Inc.

1967 - Seminar Program, Dept. of Biochemistry and Molecular Biology, Corneil University, Ithaca, N.Y.

1967 - Section of Genetics, Development and Physiology, Corneil University, Ithaca, N.Y.

02/67 - Charles F. Kettering Research Laboratory, Yellow Springs, Ohio (Lecture award)

1968 - Depart. of Biology, University of Puerto Rico Agricultural Station, University of Puerto Rico

1968 - Dept. of Biochemistry, Puerto Rico Nuclear Center, U.S.A. Atomic energy Commission (Lecture award)

1968 - Dept. of Chemistry, University of Puerto Rico, Rio Piedras

1969 - Seminar Program, Dept. of Zoology, NCAS, Rutgers University

7/70 - Section of Biochemistry, Institute of Microbiology “Malbran” Buenos Aires

7/70 - Dept. of Biological Chemistry, School of Medicine, University of Buenos Aires

7/70 - Institute Campomar, Buenos Aires

1/71 - Section of Biochemistry, Agricultural & Experimental Station, Rutgers University, New Brunswick

7/71 - Dept. of Biochemistry, Hebrew University, Jerusalem, Israel

6/71 - Dept. of Biochemistry, New Jersey College of Medicine arid nentistry, Newark

9/71 - Seminar Program Dept. of Chemistry, NCAS, Rutgers University

5/72 - Dept. of Biology, Newark State College

3/72 - The Institute for Enzyme Research, University of Wisconsin (Lecture award)

7/72 - Dept. of Biochemistry, School of Pharmacy and Biochemistry, university of Buenos Aires

1973 - Dept. of Biochemistry, School of Medicine, University of Puerto Rico (Lecture award)

7/73 - lecture at the Zentralinstitut fur Molekularbiologie, Akademie der Wissenschaften der DDR, Berlin Buch 1115, DDR

1974 - Zentralinstitut fur Molekularbiologie, Berlin Buch 1115, DDR

7/74 - Dept. of Biochemistry, School of Medicine, University of Buenos Aires

7/74 - Professional course and workshop in Metabolic Regulation. Biochemical Association, San Juan, Argentina, upon invitation to organize and teach the course

7/74 - Conference on television Estorneil Channel, Argentina

3/75 - Lecture award at the Chemistry Institute, University of Sao Paulo, Brasil

7/77 - Institute of Enzymology, School of Medicine, Universidad Autonoma, Madrid, Spain

12/77 - Biochemistry Department, School of Pharmacy and Biochemistry, University of Buenos Aires

12/77 - Lecture award at the Biochemical Association, San Juan, Argentina

12/78 - Department of Biological chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires

12/78 - Department of Biochemistry, School of Medicine, University of Buenos Aires

12/78 - Institute Campomar of Medical Research as guest of Director Luis F. Leloir, Nobel Laureate

1/79 - Lecture presented at Dept. of Biological Chemistry, School of Medicine, and Dept. of Biochemistry, School of Pharmacy, University of Buenos Aires

7/80 - Differential properties of adenylate cyclase from hypothalamus, corpus striatum and cortex. A. Bennun. Seminar, Dept. of Physio. and Biophys., C.I.E.A., natl. Polytech. Inst., Mexico City.

7/80 - Properties of fat cell adenylate cyclase".  A. Bennun. Seminar, Dept. Physiol. and Biophys., C.I.E.A., Natl. Polytech. Inst., Mexico City.

2/82 - Workshop in adenylate cyclase.  School of Pharmacy and Biochemistry, University of Buenos Aires

2/82 - Role of ionic equilibria in the control of adenylate cyclase activity. Department of Biological Chemistry, School of Chemical Sciences, University of Cordoba

3/82 - Dynamic controls of metabolic pathways. Biochemical Society of San Juan

5/82 - Workshop in interactions of coupling factors from chloroplasts with components of the chloroplast membrane. Biochemistry Section, Weizmann Institute of Science, Rehovot

12/83 - Adenylate cyclase - control mechanisms, workshop; School of Pharmacy and Biochemistry, University of Buenos Aires

1/84 - Hexose cycle in the erythroclyte, workshop, School of Pharmacy and Biochemistry University of Buenos Aires

1/85 - “Thermodynamics of hydrogen bondino and protein structure in hemoglobin and deoxyhemoglobin", workshop in the Division of Physical Chemistry, Department of Biological Chemistry, School of pharmacy and Biochemistry; University of Buenos Aires

9/85 - “A model for the regulation of hemoglobin affinity for oxygen"

9/86 - Department of Biochemistry and molecular Genetics, Pasteur Institute, Paris

9/85 - Divalent metals in the regulation of hemoglobin affinity for oxygen:, Department of Structural Immunology, Pasteur Institute, Paris

9/85 - "Hemoglobin structure and function", Biology Section, Curie Institute, Orsay, France

12/85 - Mechanism of cooperativity and hemoglobin function", Division of Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Bs As.

12/85 - “Thermodynamics of hemoglobin function", research Department National Institute Mario Fatala Chaben, Ministry of Health and Social Action of Argentina, Bs As.

 

B. MEMBERSHIPS TO THE EDITORIAL BOARDS OF SCIENTIFIC JOURNALS

1975 – 1978 - Member of the Editorial Board of “Science of Biology Journal"

1978 – 1983 - Member of the Editorial Board of Journal of Bioenergetics and Biomembranes - Plenum Press

1976 - Reviewer for Biosystems

1979 - Reviewer for the Journal Cancer Biochemistry Biophysics

1983 - Present Reviewer for the Journal of Toxicology and Environmental Health

1983 - Present Member of the Editorial Board of Journal of Toxicology and Environmental Health, Hemisphere  Publishing Corporation

 

C. MEMBER OF THE FOLLOWING SCIENTIFIC SOCIETIES

 

1969 – 1982 - American Chemical Society, Division of Biological Chemistry

1969 – Present - American Society of Plant Physiology

1969 – 1981 - Genetics Society of America

1969 – 1974 - American Nuclear Society, radioisotopes and education divisions

1970 to Present - Biophysical society, Bioenergetics group

1970 to present - New York Academy of Sciences

1972 – 1974 - Federation of American Scientists

1972 – 1981 - Argentine Society of Biochemical Research (SAIR) and Pan American Association of Biochemical Societies (PAABS)

1974 – 1978 - American Society for Photobiology

1974 to present - The Biochemical society arid Federation European Biochemical Societies (FEBS)

1976 – 1978 - Society for Supramolecular Biology

1977 to present - American Society of Biological Chemists, Inc. and Federation of American Societies for Experimental Biology (FASEB)

1979 to present - American society of Zoologists

 

D. CHAIRING OF SCIENTIFIC CONFERENCES

Chairman, Biochemistry Platform Session 1, morning Annual Minority Biomedical Research Support (NBRS) the Division of Research Resotirces of the National The Fairmont Hotel, New Orleans, La., April 16-20, of April 17, the l4th Symposium, sponsored by of Health, Institutes 1986.

Chairman, Biochemistry Platform Session 2, afternoon of April 17, the l4th,Amual Minority Biomedical Research Support (KBRS) symposium sponsored by the Division of Research Resources of the National Institutes of Health The Fairmont Hotel, New Orleans, La., April 16-20, 1986.

 

E. ATTENDANCE TO ADVANCE SCIENTIFIC STUDIES INSTITUTES

1958 - U.S. department of State, Northwestern University and University of Buenos Aires, Advanced Study Program for the use of radioisotopes in Biology by Profs. J.A.B. Cooper and M. Lipton of the Northwestern Univ. in the Dept. of Biological Physics, School of Medicine, Univ. of Buenos Aires

9/72 -  N.A.T.O. Advanced Study Institute on "Primary Molecular Events in Photobiology", Fiesole, Italy, upon invitation

 

F. PROFESSIONAL. SERVICE

1970 - Has acted as reviewer for grant applications by request of the National Science Foundation

1973 - Served as National Institute of Health supported consultant for the School of Medicine, University of Puerto Rico

1973 - Member of the consultant organization of the Biophysical Society

1975 – 1976 - Member of the committee on Bioenergetics of the International Union of Pure and Applied Biophysics (IUPAB)

1981 - Consultant New Jersey Schools Board Association

1982 - Evaluator, Committee on an assessment of quality-related characteristics of Research-Doctorate programs, National Research Council, In progress.

1977 - Member, Public Health Panel.  New Jersey Association of Hispanic Human Services Professionals.  In progress

1980 - Chairman, Public Relations Committee.  New Jersey chapter of National Image, Inc.

1980 - Consultant NIH - In progress

1983 - Participant in the NIGNS, NIH funded “Visiting Scientists for Minority Institutions Program”. Listed in roster of available scientists.

 

G. MEMBER OF NON-ACADENIC INSTITUTIONS

1970 – 1972 - Sigma XI, Rutgers Chapter

1975 - Smithsonian Institution

1977 – 1979 - New Jersey Association of Hispanic Human Services Professions (NJAHHSP)

1978 – 1979 - International Platform Association

1978 – National IMAGE, Inc.

 

H. LISTED IN BIOGRAPHICAL PUBLICATIONS

American Men of Science, (1970) Bowker Co., 11th edition, supplement 6, p. 48, ACS Directory of Graduate Research, (1975)

 

I. BY NOMINATION

International Scholars Directory, International Scholarly publishers, first edition p. 17, 1972

Who's Who in the East, Narquis Who's Who, Inc., 1Sth edition, p. 50, 1975, 1976

1978 -  listing in special section of Who's who in America Comunity leader:and Noteworthy American:, American Biographical Institute, Bicentennial edition, pp. 69 & 70 1975, 1976

Dictionary of International Biography, International Biographical Center, Cambridge, England, p. 63, 1977

 


V. GRANTS RECEIVED

11/65 – 11/66 - USPHS Natl. Cancer Inst. (CA-87-66 supply allowance) Resolution and Reconstitution of chloroplasts:  $500

10/67 – 05/68 - University of Puerto Rico Research Fund Resolution and reconstitution  of chloroplast: $10,000 Technical assistance allowance $71600

09/68 – 08/71 - USPHS Natl. Inst. Genl. Medical Sciences 1-Rol GM 16390-91 Resolution and reconstitution of developing membranes: $18,860; 02: $10,798; 03: $15,885

09/69 – 08/79 - USPHS Natl. Inst. Genl. Medical Sciences Resolution and reconstitution of developing membranes: $15, 110

7/77 – Warner-Lambert Co. - Regulatory effects of hormones on adenylate cyclase from rat's fat cells; Research materials $16,000

10/77 – Mallinckrodt Nuclear - Research materials $2,500

8/69 – 8/77 - Research Corporation - Characterization of the functional properties of a structural resolved factor by the effect of its antiserum on photophosphorylation $8,000

11/75 – International Union of Biochemistry - Travel grant to 7Sth International Union of Biochemistry Symposium $200

1984 – 1986 - Bristo-Myer:  Estimated value - equipment $3,000; supplies $1,000

1985 – 1986 - Schering Plough Company - Estimated value - supplies $800

1986 - Hoffmann-LaRoche:  Estimated value equipment $18,200; supplies $1000

1984 - Develop contact, preliminary grant application, acted as Program coordinator for the initial NIH visitation and coordinator for the research units of Rutgers – Newark requesting participation in the Minority Biomedical Research Support Program (MBRSP) of NIH Division of Research Resources. The MBRSP application initiated by Dr. Bennun was awarded 9/27/84 as 6RS rant No. 1S06RR08223 01 to 00003 from 9/30/84 trough 9/29/87 to Hathannson, Dean of the Graduate School as principal investigator to administer the funding of about 12 associate investigator’s independent sub-projects working at several departments in NCAS. Direct costs: 1st year $107,370; 2nd year $223,792, and 3rd year $228,761 plus indirect costs

07/84 – 06/85 - Independent Associate Investigator College research award   $10,934 MBRSP (5S06RR08228)

06/85 – 06/86 - Independent Associate Investigator College research award   $13,241 MBRSP (5S06RR08228)

06/86 – 06/87 - Independent Associate Investigator MBRSP (5S06RR08228) College research award   $13,394 (Principal Investigator:  Dean of Graduate School-Newark whose 0ff ice administers the grant for the independent research associate investigator)

Minority High School Student Research Apprentice Program of the National Institutes of Health Biomedical Research Support Program at Rutgers, Newark *2S03RR03095-05:

1982 Allocation: Student $1,500; supplies - $500

1983 Allocation: Student $1,500; supplies - $500

1984 Allocation: Student $1,500; supplies - $500

1985 Allocation: Student $1,500; supplies - $500

1986 Allocation: Student $1,500; supplies - $300

 

 

Biomedical Sciences Support Grant:  USPHS FR7059:

07/69 – 05/70 - Resolution and reconstitution of biomembranes $1,0OO

06/70 – 05/71 - Resolution and reconstitution of biomembranes $400

06/71 – 05/72 - Resolution and reconstitution of biomembranes $1,000

06/72 – 05/73 - Interaction between coupling factor 1 arid ligands  arid their relevance to membrane phenomena $1,000

06/7305/74 - Hormonal-dependent modification of adenylate cyclase $800

06/75 – 05/76 - Hormonal - dependent modification of adenylate cyclase $600

04/76 – 03/77 - Hormonal and metabolic control of adenylate cyclase in rat's brain $600

04/77 – 03/78 - Hormonal regulation of adenylate cyclase $600

04/78 – 03/79 - Hormonal regulation of adenylate cyclase $600

04/79 – 03/80 - Hormonal regulation of adenylate cyclase $800

04/80 – 03/81 - Hormonal regulation of adenylate cyclase $800

04/81 – 03/82 - Hormonal regulation of adenylate cyclase $800

04/82 – 03/87 - Regulation of renin release $500 every year

 

Rutgers Research Council Grants

06/89 – 06/70 - Resolution and reconstitution of biomembranes $2,500

07/70 – 06/71 - Travel grant Photobiology Symposium of the V° of Biological Sciences $500

08/72 – 05/73 - Travel grant $500

12/72 – 05/73 - Physio-chemical forces that result in modification of enzyme activity $1,000

06/73 – 05/74 - Interaction between coupling factor and ligands $750

06/77 – 05/78 - Hormonal control of rat's fat cells adenylate cyclase $500

06/81 – 05/82 - The Effect of hormones on adipocyte adenylate cyclase $500

 

Charles and Johanna Busch Memorial Fund

1974 – 1975 - The role of enzyme modification in the friction and panthophysiology of membranes $6, 500

09/74 – 11/74 Visiting scientist under the Academic Leave Program of Rutgers University at the Laboratoire d'Enzimologie Centre National de la Recherche Scientifique France

 

FASP Grants Committee

07/78 – 12/78   Hormonal regulation adenylate cyclase system $500

 

Grants to Obtain Grants

04/78 – For general support $260

 


SCHOLARLY/CREATIVE ACTIVITIES

 

VI. TEACHING

1957 - Research technology, non-credit course, Dept. of histology and Embryology, School of Medicine, Univ. of Cordoba, Argentina

1958 - Sections of Experimental Biochemistry, Dept. of Biochemistry, School of Biochemistry, University of Buenos Aires

1958 – 1962 - Sections of Biological Chemistry, School of Medicine, University of Buenos Aires

1967 - 1969 - Biology 103-104, General Biology, Dept. of Biology, University of Puerto Rico

1967 - 1969 - Biology 379, Reading and Research, Dept. of Biology, University of Puerto Rico

1968 - 1969 - Biology 354, Cellular Biochemistry, Dept. of Biology University of Puerto Rico

1968 - 1969 - Biology 257, Plant Physiology, Dept. of Biology, University of Puerto Rico

 

990:494 Seminar in Zoology (1 cr)
Fall 1970, Spring 1976, Spring 1977.

115:413 Experimental Biochemistry (2 cr)
Fall 1971, Fall 1972, Fall 1973, Fall 1975, Fall 1980.

990:411 Endocrinology
Fall 1977.

115:414 Experimental Biochemistry (2cr)
Spring 1972, Spring 1973, Spring 1974.

990:204 Physiological Zoology (4 cr)
Spring 1976, Spring 1977, Spring 1978

120:101 General Biology Laboratory
Fall 1973, Spring 1974, Fall 1986

115:310 Elementary Biochemistry
Spring 1980, Spring 1984, Spring 1985, Spring 1986.

115:312 Elementary Biochemistry
Fall 1980, Fall 1983, Fall 1984, Fall 1986.

115:404 General Biochemistry
Spring 1980, Spring 1981, Spring 183, Spring 1984, Fall 1984, Spring 1985.

760:407 General Physiology
Fall 1981, Fall 1982, Spring 1979, Spring 1983.

115:405 Problems in Biochemistry
Fall 1982, Fall 1983, Spring 1984, Spring 1985.

990:491 Special Problems in Zoology
Fall 1982, Spring 1983.

 

Courses Taught (at Graduate School Rutgers University)

115:513 Metabolic Pathways Controls (3 cr)
Fall 1969, Fall 1970, Fall 1971, Fall 1972, Fall 1973, Fall 1975.

990:513 Metabolic Pathways Controls (3 cr)
Fall 1975, Fall 1976, Fall 1977, Fall 1979.

115:514 Metabolic Pathways Mechanisms (3 cr)
Spring 1970, Spring 1971, Spring 1972

990:514 Metabolic Pathways Mechanisms (3 cr)
Spring 1973, Spring 1974, Spring 1976, Spring 1977, Spring 1978.

990:511 Advanced Endocrinology (3 cr)
Fall 1976, Fall 1977, Fall 1979, Fall 1980, Fall 1981.

990:616 Special Topics in Biochemistry (1 cr)
Fall 1975, Spring 1976, Spring 1977, Fall 1977, Spring 1978, Spring 1979, Spring 1984, Fall 1984, Spring 1985, Fall 1985.

115:606 Advanced Studies in Biochemistry
Spring 1974

115:701 Research in Zoology
1969 to Present

990:509 Advanced Problems in Zoology
Summer 1976, Spring 1977, Summer 1978, Spring 1979, Fall 1978, Fall 1985.

160:572 Biochemistry
Spring 1980, Spring 1981, Spring 1984, Spring 1985, Spring 1986

 


Supervision of Honors Thesis Completed by Students in the Undergraduate Honors Program:

1969 1968 -        W. Velez-Vega and M. Dieppa - Honors Program Advisor -Biology Department University of Puerto Rico

1981 - Nancee A. Novak - The effect of cyclic nucleotides upon glycolysis in the human erythrocyte

1982 - Bessie B. Fouces - Kinetic studies on brain adenylate cyclase

1984 - Sylvia Menendez - The role of energy charge in the regulation of brain adenylate cyclase activity

 

Summer Supervision of Minority High School Students with Research Apprentice Program of NIH-BRSP

1982  Patricia Grady

1983  Patricia Grady

1984  James Anderson

1986  Manuel Dasilva

 

VII. UNIVERSITY SERVICE

1967 – 1969 - Member of the Graduate Faculty, Department of Biology, University of Puerto Rico

1970 - Full member of the graduate School of Rutgers University.

1970 - Full member of the cooperative Graduate Program in Biochemistry, Rutgers University.

1970 – 1973 - Member of the University Science Council, Rutgers University

1975 - . Member of the Academic Standards Committee of the Cooperative Graduate Program of Biochemistry.

1970 - Member of several graduate students’ committees in the Graduate Program in Biochemistry

1970 - Full member Graduate Program in  Zoology. NCAS

1970 - Member of several graduate students  committees in the Graduate Program in Zoology NCAS

1975 – 1978 - Member of the NCAS Academic Affairs Committee

1977 – 1978 - Member of NCAS Graduate School Planning Committee

1979 – 1981 - Member of NCAS Graduate School Planning Committee

1977 – 1978 - Member of Curriculum Committee, Dept. of Zoology and Physiology NCAS

1978 - Member of Executive Committee of the Graduate Program in Zoology NCAS

1979 - Member of Teaching Evaluation Committee NCAS

1978 - Member , Cancer Coordinating Committee of Rutgers, Newark NCAS

1983, 1985 - Member, Executive Committee Graduate Program in Zoology NCAS

1984 – 1986 - Member of the advisory committee for MBRS program in Newark Campus of Rutgers.

 

 

VIII. GRADUATE STUDENT SUPERVISION

Supervision of Ph.D. candidates research and titles of Ph.D. dissertations completed by students under my direction and initial post-doctoral positions:

 

Susan B. Golz - Regulation of brain adenylate cyclase by physiological and pharmacological factors.  Ph.D. in Zoology awarded May 1976. Initial Position: Assistant Professor, Bergen Community college.

Robert H. Harris - Hormonal regulation of rat fat cell CAMP levels and fat ceil membrane adenylate cyclase.  Ph.D. in Biochemistry awarded November 1977.  Initial Position: Research specialist, Division of Metabolism of Food and Drug Administration, Bethesda, MD.

Heripsime Ohanian - The role of divalent metals, adenosine 5'-triphosphate and hormones in the regulation of rat brain adenylate cyclase.  Ph.D. in Zoology awarded June 1980.  Initial Position: Medical School, Lille University, France.

Vincent A. DeBari - Regulation of the hexose monophosphate pathway in cyclic nucleotides and divalent cations in the human erythrocyte. Ph.D. in Zoology awarded May 1981. Initial Position: Director, Renal laboratory, St. Joseph's Hospital, Paterson, N.J.

Joseph W. Sulner - Renal renin release - a stimulatory role for Calcium Ph.D. in Zoology awarded May 1984.  Postdoctoral Hoffman – Laroche. Initial Position: Associate Investigator N.Y. Veteran's Hospital.

Rafaela Cruz - The integration of hormones, Ng 2+ Ca2+ and their nucleotide complexes on the regulation of brain adenylate cyclase. Ph.D. in Zoology awarded October 1986. Initial Position: Adjunct Faculty in Anatomy and Physiology at Upsala College, East Orange, N.J..

Pasquale Vicario – The regulation of Insulin Receptor Tyrosine Kinase by Insulin, Divalent metal cations and metal – ATP substrate. Ph. D. in Zoology awarded May 1988. Initial Position: Investigator at Merck Company.

Christopher Casciano – The pharmacological characterization of the bicarbonate, proton, and mucus transport systems of the rodent gastric mucosa and their significance in cytoprotection. Ph. D. in Zoology awarded September 1988. Initial Position: Investigator at Schering Company.

 

Supervision of Ph.D. candidates research under my direction:

1984  G. Serban

1985  P. Uychich

1985  L. Rumennick

Supervision of Masters candidates research and Masters Thesis completed by students:

1975 - Chairman of the committee for the Master in Zoology of Susan Brydon Golz. M. Sc. awarded 1975.

1978 - Chairman of the committee for the Master in Zoology of Heripsime Ohanian. M. Sc. awarded 1978.

1981 - Chairman of the committee for the Master in Zoology of Rafaela Cruz. M. Sc. awarded 1981

Supervision of research:

1968 – 1969 - Advisor in the Biology Program to 1. Bulla, M.S. candidate at university of Puerto Rico

1970 – 1971 - Advisor in the Graduate Program of Biochemistry to E. Albanese and V. Cannistraro.

1970 – 1971 - Advisor in the Master in Zoology Sciences Program to E. Wallendjack

1977 - Research advisor to Kamran Borhanian, student at NJCMD, Rutgers Medical School

1977 - Postdoctoral research advisor to Salette de Farias on a leave from Institute Butantan, Sao Paulo, Brazil

1984 - Research advisor to Norbert Seidler, student at NJCMD, Rutgers Medical School

Membership on Graduate Student Committees:

1974 - Vincent Rama (Ph.D., Zoology)

1977 - Jeff Stevens (M.S., Biochemistry)