Erythrocyte transport of cyclic nucleotide
Novembre, P., Nicotra, J., De Bari, V.A., Needle, N.A. and
Bennun, A.
Although the regulatory activities of cyclic nucleotides have
been well studied in a diverse group of nucleated cells, the
subject of their role in the erythrocytes of higher mammals
has been somewhat controversial. Central to this controversy
has been the failure to detect any appreciable activity of
the enzymes adenylate cyclase and guanylate cyclase, responsible
for the formation of cAMP and cGMP, respectively. One explanation
for the finding of significant concentrations of cAMP and
cGMP within these cells is the transport of these substances
from the extracellular fluid, especially at physiological
concentrations of the cyclic nucleotides in plasma. In this
paper we report studies on the transport kinetics of cAMP
and cGMP within the range of concentrations observed in humans.
Annals of the New York Academy of Sciences, 435, (1984), 190-194